Product Pathways - Metabolism
TXNIP (D5F3E) Rabbit mAb #14715
EST01027 HHCPA78 sc-271238 sc-33099 THIF thioredoxin binding protein 2 thioredoxin interacting protein Thioredoxin-binding protein 2 Thioredoxin-interacting protein TXNIP upregulated by 1.25-dihydroxyvitamin D-3 VDUP1 Vitamin D3 up-regulated protein 1
|14715S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|14715||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
TXNIP (D5F3E) Rabbit mAb recognizes endogenous levels of total TXNIP protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val337 of human TXNIP protein.
Western blot analysis of extracts from various cell lines using TXNIP (D5F3E) Rabbit mAb.
Immunoprecipitation of TXNIP from RL-7 cell extracts using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or TXNIP (D5F3E) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using TXNIP (D5F3E) Rabbit mAb. Mouse Anti-rabbit IgG (Light-Chain Specific) (L57A3) mAb #3677 was used as the secondary antibody.
The ubiquitously expressed thioredoxin-interacting protein (TXNIP) binds and inhibits thioredoxin to regulate cellular redox state (1-3). Research studies demonstrate that hyperglycemia induces TXNIP expression and increases cellular oxidative stress (1). In addition, these studies show that TXNIP reduces glucose uptake directly by binding the glucose transporter Glut1 to stimulate receptor internalization or indirectly by reducing Glut1 mRNA levels (3). Additional studies indicate that TXNIP plays a role in the regulation of insulin mRNA transcription (4). Microarray analyses indicate that TXNIP acts downstream of PPARγ and is a putative tumor suppressor that may control thyroid cancer cell progression (5). In addition, the TXNIP protein may be a potential therapeutic target for the treatment of type 2 diabetes and some disorders related to ER-stress (6).
- Schulze, P.C. et al. (2004) J Biol Chem 279, 30369-74.
- Saxena, G. et al. (2010) J Biol Chem 285, 3997-4005.
- Wu, N. et al. (2013) Mol Cell 49, 1167-75.
- Xu, G. et al. (2013) Nat Med 19, 1141-6.
- Morrison, J.A. et al. (2014) Mol Cancer 13, 62.
- Robinson, K.A. et al. (2013) J Mol Endocrinol 50, 59-71.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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