Product Pathways - Vesicle Trafficking
Sec24D (D9M7L) Rabbit mAb #14687
|14687S||100 µl ( 10 western blots )||￥3,250.00||现货查询 购买询价 防伪查询|
|14687||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
Sec24D (D9M7L) Rabbit mAb recognizes endogenous levels of total Sec24D protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro80 of human Sec24D protein.
Western blot analysis of extracts from various cell lines using Sec24D (D9M7L) Rabbit mAb.
Coat Protein Complex II (COPII) is composed of five cytosolic proteins: Sec23/24 complex, Sec13/31 complex, and Sar1. COPII coat is located at the ER/Golgi interface and is involved in transport of newly synthesized proteins from the ER to the Golgi apparatus (1). COPII formation is initiated through the binding of the activated G protein, Sar1, to the Sec23/24 complex, thereby forming a prebudding complex that directly binds target molecules (1-3). The prebudding complex further recruits Sec13/31 to form mature COPII coat (4,5). The Sec24 subunit of COPII coat is thought to play a critical role in cargo selection (2,6). It binds directly to cargo proteins at the ER and brings them to COPII vesicles through interaction with Sec23. There are four Sec24 isoforms in human cells: Sec24A, Sec24B, Sec24C, and Sec24D (7). In mice, mutations in Sec24B have been linked to developmental defects (8,9).
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- Merte, J. et al. (2010) Nat Cell Biol 12, 41-6; sup pp 1-8.
- Wansleeben, C. et al. (2010) Development 137, 1067-73.
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