Cell Signaling Technology

Product Pathways - Metabolism

ANT2/SLC25A5 (E2B9D) Rabbit mAb #14671

2F1   AAC2   Adenine nucleotide translocator 2   adenine nucleotide translocator 2 (fibroblast)   adenine nucleotide translocator). member 5   ADP.ATP carrier protein 2   ADP.ATP carrier protein. fibroblast isoform   ADP/ATP carrier protein   ADP/ATP translocase 2   ADT2   ANT 2   ANT2   SLC25A5   solute carrier family 25 (mitochondrial carrier   Solute carrier family 25 member 5   T2   T3  

No. Size Price
14671S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
14671 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat,Monkey, Endogenous 29 Rabbit IgG
IP 1:50

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,

Specificity / Sensitivity

ANT2/SLC25A5 (E2B9D) Rabbit mAb recognizes endogenous levels of total ANT2/SLC25A5 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly156 of human ANT2/SLC25A5 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using ANT2/SLC25A5 (E2B9D) Rabbit mAb.

IP

IP

Immunoprecipitation of ANT2/SLC25A5 from MCF7 cell extracts using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or ANT2/SLC25A5 (E2B9D) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using ANT2/SLC25A5 (E2B9D) Rabbit mAb.

Background

Adenine nucleotide translocase 2 (ANT2/SLC25A5) is a member of the adenine nucleotide translocase family of mitochondrial inner membrane proteins that function differently in metabolic and apoptotic pathways (1). Research studies indicate that ANT2 expression in undifferentiated, proliferating cells correlates with the rate of glycolytic metabolism and may be an indicator of carcinogenesis (2). Suppression of ANT2/SLC25A5 expression by specific RNA interference in human breast cancer cells promotes apoptosis and inhibits tumor cell growth (2), which suggests a cytoprotective role of ANT2/SLC25A5 (1,3).

  1. Brenner, C. et al. (2011) Oncogene 30, 883-95.
  2. Chevrollier, A. et al. (2011) Biochim Biophys Acta 1807, 562-7.
  3. Jang, J.Y. et al. (2008) Breast Cancer Res 10, R11.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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