Cell Signaling Technology

Product Pathways - Metabolism

HSD17B6 (D1T5H) Rabbit mAb #14669

17-beta-HSD 6   17-beta-HSD6   17-beta-hydroxysteroid dehydrogenase type 6   3(alpha->beta)-hydroxysteroid epimerase   3(alpha->beta)-hydroxysteroid epimerasel   3-alpha->beta-HSE   3-alpha->beta-hydroxysteroid epimerase   3-hydroxysteroid epimerase   H17B6   HSD17B6   HSE   hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)   NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase   Oxidative 3-alpha hydroxysteroid dehydrogenase   oxidative 3-alpha-hydroxysteroid-dehydrogenase   oxidoreductase   retinol dehydrogenase   RODH   SDR9C6   short chain dehydrogenase/reductase family 9C. member 6  

No. Size Price
14669S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
14669 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Endogenous 29 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

HSD17B6 (D1T5H) Rabbit mAb recognizes endogenous levels of total HSD17B6 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu220 of human HSD17B6 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from human liver (positive), kidney (negative), and colon (negative) tissues using HSD17B6 (D1T5H) Rabbit mAb (upper) and GAPDH (D16H11) XP® Rabbit mAb #5174 (lower).

Background

The type 6 17-β-hydroxysteroid dehydrogenase (HSD17B6, 17-β-HSD 6) regulates cellular hydroxysteroids by catalyzing the conversion of androsterone to epiandrosterone (1). This enzyme displays both oxidoreductase and epimerase activities, and is also known as 3(α->β)-hydroxysteroid epimerase. The interaction between HSD17B6 and hydroxysteroid compounds has an important effect on steroid activity as these compounds typically act in a stereo-specificity manner (1). Research studies show that the transcriptional activity of androgen receptor in prostate cell lines treated by androstanediol correlates with HSD17B6 protein level, which suggests an important role for enzyme in prostate cancer growth (2).

  1. Huang, X.F. and Luu-The, V. (2000) J Biol Chem 275, 29452-7.
  2. Mohler, J.L. et al. (2011) Cancer Res 71, 1486-96.

Application References

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Protocols


For Research Use Only. Not For Use In Diagnostic Procedures.

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