Product Pathways - Metabolism
HSD17B6 (D1T5H) Rabbit mAb #14669
17-beta-HSD 6 17-beta-HSD6 17-beta-hydroxysteroid dehydrogenase type 6 3(alpha->beta)-hydroxysteroid epimerase 3(alpha->beta)-hydroxysteroid epimerasel 3-alpha->beta-HSE 3-alpha->beta-hydroxysteroid epimerase 3-hydroxysteroid epimerase H17B6 HSD17B6 HSE hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse) NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase Oxidative 3-alpha hydroxysteroid dehydrogenase oxidative 3-alpha-hydroxysteroid-dehydrogenase oxidoreductase retinol dehydrogenase RODH SDR9C6 short chain dehydrogenase/reductase family 9C. member 6
|14669S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|14669||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting,
Specificity / Sensitivity
HSD17B6 (D1T5H) Rabbit mAb recognizes endogenous levels of total HSD17B6 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu220 of human HSD17B6 protein.
The type 6 17-β-hydroxysteroid dehydrogenase (HSD17B6, 17-β-HSD 6) regulates cellular hydroxysteroids by catalyzing the conversion of androsterone to epiandrosterone (1). This enzyme displays both oxidoreductase and epimerase activities, and is also known as 3(α->β)-hydroxysteroid epimerase. The interaction between HSD17B6 and hydroxysteroid compounds has an important effect on steroid activity as these compounds typically act in a stereo-specificity manner (1). Research studies show that the transcriptional activity of androgen receptor in prostate cell lines treated by androstanediol correlates with HSD17B6 protein level, which suggests an important role for enzyme in prostate cancer growth (2).
- Huang, X.F. and Luu-The, V. (2000) J Biol Chem 275, 29452-7.
- Mohler, J.L. et al. (2011) Cancer Res 71, 1486-96.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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