Product Pathways - Transcription Factors
Miz-1 (D7E8B) Rabbit mAb #14300
|14300S||100 µl ( 10 western blots )||￥3,250.00 现货查询||购买询价|
|14300||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
Miz-1 (D7E8B) Rabbit mAb recognizes endogenous levels of total Miz-1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro161 of human Miz-1 protein.
Western blot analysis of extracts from various cell lines using Miz-1 (D7E8B) Rabbit mAb.
Miz-1 (Zbtb17) is a poxvirus and zinc finger (POZ) transcription factor with an amino-terminal BTB/POZ domain and 13 carboxy-terminal zinc finger domains. Miz-1 plays a key role in cell cycle control through activation of the cyclin-dependent kinase inhibitors p15, INK4B, and p21 Waf1/Cip1 (1-4). The transcriptional activity of Miz-1 is repressed through direct interaction with Myc (1-4). In the presence of DNA damage, Myc is recruited to the p21 Waf1/Cip1 promoter by Miz-1 and blocks p53-mediated induction of p21 Waf1/Cip1, ultimately resulting in p53-mediated apoptosis rather than cell cycle arrest (4). Miz-1 also plays a role during lymphocyte development. In developing B and T cells, Miz-1 represses suppressor of cytokine signaling 1 (SOCS1) expression, which enables signaling through the IL-7 receptor and upregulation of the pro-survival protein Bcl-2 (5,6).
- Peukert, K. et al. (1997) EMBO J 16, 5672-86.
- Seoane, J. et al. (2001) Nat Cell Biol 3, 400-8.
- Staller, P. et al. (2001) Nat Cell Biol 3, 392-9.
- Seoane, J. et al. (2002) Nature 419, 729-34.
- Kosan, C. et al. (2010) Immunity 33, 917-28.
- Saba, I. et al. (2011) Blood 117, 3370-81.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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