Cell Signaling Technology

Product Pathways - Protein Translation

ATP2A1/SERCA1 (D54G12) Rabbit mAb #12293

AT2A1   ATP2A   ATP2A1   ATPase. Ca++ transporting. cardiac muscle. fast twitch 1   ATPase. Ca++ transporting. fast twitch 1   Calcium pump 1   Calcium-transporting ATPase sarcoplasmic reticulum type. fast twitch skeletal muscle isoform   Endoplasmic reticulum class 1/2 Ca(2+) ATPase   Sarcoplasmic/endoplasmic reticulum calcium ATPase 1   SERCA1   SR Ca(2+)-ATPase 1  

No. Size Price
12293S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
12293 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse, Endogenous 100 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,


Species predicted to react based on 100% sequence homology: Rat,

Specificity / Sensitivity

ATP2A1/SERCA1 (D54G12) Rabbit mAb recognizes endogenous levels of total ATP2A1/SERCA1 protein.

ATP2A1/SERCA1 (D54G12) Rabbit mAb兔单抗识别内源性的总ATP2A1/SERCA1蛋白。

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro995 of human ATP2A1/SERCA1 protein.


Western Blotting

Western Blotting

Western blot analysis of extracts from human skeletal muscle and mouse skeletal muscle using ATP2A1/SERCA1 (D54G12) Rabbit mAb.

Western blot方法检测人和小鼠骨骼肌组织提取物,使用的抗体为ATP2A1/SERCA1 (D54G12) Rabbit mAb.


Sarcoplasmic and endoplasmic reticulum Ca2+ ATPases (SERCA) are members of a highly conserved family of Ca2+ pumps (1). SERCA pumps transport Ca2+ from the cytosol to the sarcoplasmic and endoplasmic reticulum lumen against a large concentration gradient (1). ATP2A1 (SERCA1) is a fast-twitch, skeletal muscle sarcoplasmic reticulum Ca2+ ATPase (2). Research studies have shown that mutations in the ATP2A1 gene cause an autosomal recessive muscle disorder known as Brody myopathy, which is characterized by muscle cramping and impaired muscle relaxation associated with exercise (1-3).

肌质和内质网Ca2+ ATPases(SERCA)是一个高度保守的Ca2+泵家族成员(1)。SERCA泵将细胞质内Ca2 +沿逆向浓度梯度运输到肌质和内质网(1)。ATP2A1 (SERCA1)是一个快速转换的骨骼肌肌质网Ca2+ATPase(2)。研究表明,ATP2A1基因突变会导致常染色体隐性遗传肌紊乱,就是已知的布罗迪肌病,其特点是运动时伴有肌肉痉挛和肌肉松弛受损(1-3)。

  1. Hovnanian, A. (2007) Subcell Biochem 45, 337-63.
  2. Odermatt, A. et al. (1996) Nat Genet 14, 191-4.
  3. Odermatt, A. et al. (2000) Hum Genet 106, 482-91.

Application References

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Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

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