Cell Signaling Technology

Product Pathways - Neuroscience

Tenascin C (D16C4) Rabbit mAb #12221

No. Size Price
12221S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
12221 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat, Endogenous 240 Rabbit IgG
IP 1:50

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,

Specificity / Sensitivity

Tenascin C (D16C4) Rabbit mAb recognizes endogenous levels of total Tenascin C protein. This antibody also cross-reacts with a protein of unknown origin at 120 kDa.

Tenascin C (D16C4) Rabbit mAb能够检测内源性的肌腱蛋白C总蛋白。该抗体可能会与未知来源的120 kDa蛋白产生交叉反应。

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Tenascin C protein.


Western Blotting

Western Blotting

Western blot analysis of extracts from mouse brain and rat brain using Tenascin C (D16C4) Rabbit mAb.

Western blot 检测小鼠大脑和大鼠大脑提取物,使用的抗体是Tenascin C (D16C4) Rabbit mAb兔单抗。


Tenascin C is a large hexameric extracellular matrix glycoprotein that exhibits de-adhesive effects on cell-matrix interaction, enhancing cell proliferation and motility in most cell types. It is highly expressed in remodeling tissues during embryonic development and under pathological conditions in adults, and research studies have shown markedly increased expression in cancerous tissues (1,2). Tenascin C has been implicated in a variety of cellular processes relevant to atherosclerosis, including cell proliferation, migration, and apoptosis. Expression of Tenascin C is tightly controlled in adults and is upregulated in tissues undergoing wound healing (3). In development, the expression of Tenascin C is known to be associated with epithelial-mesenchymal transition (EMT) events including gastrulation and formation of the neural crest, endocardial cushion, and secondary palate (1). Investigators have shown that Tenascin C is a key determinant of the tumor stroma and that it is involved in the initiation of tumorigenesis and progression to metastasis (2). Immature and mature astrocytes, radial glial cells, Schwann cells, and a subset of neurons express Tenascin C. Upon CNS trauma or exposure of neurons to excitotoxic agents, Tenascin C expression is upregulated by glial cells. Research studies have shown that Tenascin C is involved in guidance of migrating axons and neurons, synaptic plasticity, and neuronal regeneration, promoting spinal cord regeneration after injury (4).


  1. Imanaka-Yoshida, K. (2012) Circ J 76, 2513-20.
  2. Yoshimura, H. et al. (2011) Histol Histopathol 26, 297-305.
  3. Minear, M.A. et al. (2011) Hum Genet 129, 641-54.
  4. Chen, J. et al. (2010) Mol Ther 18, 1769-77.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

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