Cell Signaling Technology

Product Pathways - Metabolism

ALDH1A1 (D4R9V) Rabbit mAb #12035

No. Size Price
12035S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
12035 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse, Endogenous 55 Rabbit IgG
IP 1:100

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,

Specificity / Sensitivity

ALDH1A1 (D4R9V) Rabbit mAb recognizes endogenous levels of total ALDH1A1 protein.

ALDH1A1 (D4R9V) Rabbit mAb 兔单抗能够检测内源性的ALDH1A1总蛋白水平。

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse ALDH1A1 protein.


Western Blotting

Western Blotting

Western blot analysis of extracts from Hep 3B and Hep G2 cells using ALDH1A1 (D4R9V) Rabbit mAb.

Western blot 检测Hep 3B和Hep G2细胞系提取物,使用抗体为ALDH1A1 (D4R9V) Rabbit mAb兔单抗。


The aldehyde dehydrogenase family is a large group of enzymes that oxidize aldehydes formed through metabolic processes to their carboxylic acids (1). ALDH1A1 is a liver cytosolic isoform of acetaldehyde dehydrogenase and is involved in the major pathway of alcohol metabolism along with alcohol dehydrogenase (2). ALDH1A1 is also known as retinal dehydrogenase 1 and is involved in retinol metabolism, converting retinol to retinoic acid (3). Recent studies suggest that control of retinoid signaling through ALDH1A1 may influence hematopoietic stem cell differentiation (4). There has been recent interest in ALDH1 isoforms as predictive biomarkers in disease. Several studies have suggested that ALDH1A1 is a potential marker for cancer stem cells and chemoresistance in several tumor types, such as melanoma (5), lung cancer (6), glioblastoma (7).


  1. Jackson, B. et al. (2011) Hum Genomics 5, 283-303.
  2. Edenberg, H.J. (2007) Alcohol Res Health 30, 5-13.
  3. Duester, G. (2000) Eur J Biochem 267, 4315-24.
  4. Chute, J.P. et al. (2006) Proc Natl Acad Sci U S A 103, 11707-12.
  5. Luo, Y. et al. (2012) Stem Cells 30, 2100-13.
  6. Huang, C.P. et al. (2013) Cancer Lett 328, 144-51.
  7. Schäfer, A. et al. (2012) Neuro Oncol 14, 1452-64.

Application References

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Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

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