Cell Signaling Technology

Product Pathways - Metabolism

TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb #12029

KIAA1652   Selenoprotein Z   SelZ   thioredoxin reductase 2   Thioredoxin reductase 2. mitochondrial   thioredoxin reductase 3   thioredoxin reductase beta   Thioredoxin reductase TR3   TR   TR-beta   TR3   TRXR2   TXNRD2  

No. Size Price
12029S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
12029 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Monkey, Endogenous 56 Mouse IgG3

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb recognizes endogenous levels of total TRXR2/TXNRD2 protein.

TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb鼠单抗能够检测内源性TRXR2/TXNRD2总蛋白水平。

Source / Purification

Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the carboxy terminus of human TRXR2/TXNRD2 protein.


Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb.

Western blot 检测多种细胞系提取物,使用抗体为TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb鼠单抗。


Thioredoxin reductases are selenoproteins that are critical for maintaining cellular redox balance and eliminating reactive oxygen species (ROS) (1-4). There are three known mammalian thioredoxin reductases: TRXR1/TXNRD1 (cytosolic), TRXR2/TXNRD2 (mitochondrial), and TRXR3/TXNRD3 (testis-specific) (1). TRXR2 may function to protect against tumor necrosis factor-α (TNF-α)-mediated ROS generation (5). TRXR2 is critical for normal heart development and function (1,4). TRXR2 KO mice experience embryonic lethality, while mitochondrial dysfunction seen in heart-specific TRXR2 KO mice results in congestive heart failure (4). In humans, certain rare mutations in TRXR2 have been linked to dilated cardiomyopathy (1). A recent study in the EPIC-Heidelberg cohort shows that serum selenium levels, in concert with certain SNPs in TRXR2 and other selenoproteins, can influence prostate cancer risk (6).

硫氧还蛋白还原酶是硒蛋白,对于维持细胞的氧化还原平衡和消除活性氧自由基(ROS)至关重要(1-4)。有三种已知哺乳动物的硫氧还蛋白还原酶:TRXR1/TXNRD1(胞浆型),TRXR2/TXNRD2(线粒体型),TRXR3/TXNRD3(睾丸特异型)(1)。 TRXR2的功能是防止肿瘤坏死因子-α(TNF-α)介导的ROS生成(5)。 TRXR2对于心脏的正常发育和功能非常重要(1,4)。TRXR2敲除小鼠会胚胎致死,而TRXR2心脏定点敲小鼠会因线粒体功能障碍导致充血性心脏衰竭(4)。在人类中,发现了一些罕见的TRXR2基因突变伴随着扩张型心肌病(1)。EPIC-Heidelberg团队最近的一项研究表明,血清硒水平,参考TRXR2某些单核苷酸多态性和其他硒蛋白,可以影响前列腺癌的风险(6)。

  1. Sibbing, D. et al. (2011) Eur Heart J 32, 1121-33.
  2. Gasdaska, P.Y. et al. (1999) FEBS Lett 442, 105-11.
  3. Miranda-Vizuete, A. et al. (1999) Eur J Biochem 261, 405-12.
  4. Conrad, M. et al. (2004) Mol Cell Biol 24, 9414-23.
  5. Hansen, J.M. et al. (2006) Toxicol Sci 91, 643-50.
  6. Méplan, C. et al. (2012) PLoS One 7, e48709.

Application References

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Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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