Cell Signaling Technology

Product Pathways - Tyrosine Kinase / Adaptors

Phospho-DDR1 (Tyr792) Antibody #11994

No. Size Price
11994S 100 µl ( 10 western blots ) ¥3,900.00 现货查询 购买询价
11994 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Endogenous 125 Rabbit
IP 1:100

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,


Species predicted to react based on 100% sequence homology: Mouse, Rat,

Specificity / Sensitivity

Phospho-DDR1 (Tyr792) Antibody recognizes endogenous levels of DDR1 protein only when phosphorylated at Tyr792. This antibody may cross-reacts with other tyrosine-phosphorylated RTKs.

只有当Tyr792磷酸化时,磷酸化DDR1 (Tyr792)抗体能够识别内源性水平的DDR1蛋白。该抗体可能与其他酪氨酸磷酸化RTKs发生交叉反应。

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr792 of human DDR1 protein. Antibodies are purified by protein A and peptide affinity chromatography.


Western Blotting

Western Blotting

Western blot analysis of extracts from T-47D cells, untreated (-) or treated with collagen (15 μg/ml) for the indicated times, using Phospho-DDR1 (Tyr792) Antibody (upper) or DDR1 (D1G6) XP® Rabbit mAb #5583 (lower).Western blot方法检测T-47D细胞提取物,细胞不处理(-)或用胶原蛋白(15 μg/ml)处理指定的时间,使用的抗体为Phospho-DDR1 (Tyr792) Antibody (上图)或DDR1 (D1G6) XP® Rabbit mAb #5583 (下图).


The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2 (1). They are widely expressed in human tissues and may have roles in smooth muscle cell-mediated collagen remodeling (2). Research studies have implicated aberrant expression and signaling of DDRs in human diseases related to increased matrix degradation and remodeling, such as cardiovascular disease, liver fibrosis, and tumor invasion (1).

盘状结构域受体(DDRs)是一种酪氨酸激酶受体,它的胞外区有一个盘状结构同源性重复,能够被与之相结合的胞外基质胶原激活。目前已知的哺乳动物的DDRs有两种:DDR1 和DDR2 (1)。它们广泛表达于人的组织中,并有可能与平滑肌细胞介导的胶原重塑相关(2)。DDRs异常表达并激活的下游通路可能与很多和基质降解和重构增加相关的人类疾病,如心血管疾病、肝纤维化和肿瘤侵袭性疾病密切相关(1)。

Phosphorylation of DDR1 at Tyr792 was identified at Cell Signaling Technology using PTMScan®, our LC-MS/MS platform for phosphorylation site discovery (3). Tyr792 is located in the activation loop of the DDR1 kinase domain.

Cell Signaling Technology使用PTMScan®确定DDR1 Tyr792位点的磷酸化,PTMScan®是我们的磷酸化位点发现的LC-MS/MS平台(3)。Tyr792位于DDR1激酶结构域的活化环中。

  1. Vogel, W. (1999) FASEB J 13 Suppl, S77-82.
  2. Ferri, N. et al. (2004) Am J Pathol 164, 1575-85.
  3. Rikova, K. et al. (2007) Cell 131, 1190-203.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

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